Potassium Hydroxide → 2-bromo-4,5-dimethylaniline

HRID 2054450ノート

反応式

HRID 2054450 の反応式
[OH-].[K+].[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH3:11])=[CH:6][C:5]=1[NH:12]C(=O)C>CO>[Br:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([CH3:11])=[CH:6][C:5]=1[NH2:12]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 890424N-(2-Bromo-4,5-dimethylphenyl)acetamide

生成物 1

HCID 41792362-bromo-4,5-dimethylaniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

Potassium hydroxide (15.9 g, 284 mmol) was added to a stirred solution of N-2-bromo-4,5-dimethylphenyl)acetamide (1-7) (17.2 g, 71.0 mmol) in methanol (350 mL) at ambient temperature. After stirring at approximately 80° C. for 18 h, the reaction mixture was cooled and the organic volatiles removed in vacuo. The remaining aqueous phase was diluted with additional water (65 mL) and the resultant solid product was filtered, washed with water and dried in vacuo to afford 1-8 as a white solid.

後処理

  1. temperaturethe reaction mixture was cooled
  2. customthe organic volatiles removed in vacuo
  3. additionThe remaining aqueous phase was diluted with additional water (65 mL)
  4. filtrationthe resultant solid product was filtered
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-b23d21ac48cb423aa72ae0ca5e22959a
出典データセット
uspto-grants-2008_02
特許番号
US07329673B2

反応ノート

読み込み中…