関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 反応物 | 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene | HCID 22014733 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Nitro-5-(3-diethylamino-1-propoxy)aniline | HCID 22014718 | — |
反応手順
The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07329684B2 |
|---|
| 出典データセット | uspto-grants-2008_02 |
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| ORD ID | ord-533bc1d78966435e9472b359c24e93b1 |
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| 出典メモ | uspto-grants-2008_02 |
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