3,5-Dimethylaniline → 3-(3,5-Dimethylphenyl)amino-4-nitrophenol

HRID 2054629

反応式

HRID 2054629 の反応式
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[NH2:16]>C(OCC)(=O)C>[CH3:12][C:13]1[CH:14]=[C:15]([NH:16][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])[CH:17]=[C:18]([CH3:20])[CH:19]=1

参加物

4

反応物 2

HCID 79493,5-DimethylanilineHCID 5209483-Fluoro-4-nitrophenol

生成物 1

HCID 219381543-(3,5-Dimethylphenyl)amino-4-nitrophenol

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
120 °C

実験手順

5.4 g of 3-fluoro-4-nitrophenol and 4.3 ml of 3,5-dimethylaniline were mixed and stirred for 6 hours at 120° C. After cooling, it was taken up in ethyl acetate and water and extracted three times with 1N aqueous hydrochloric acid. The combined aqueous phases were extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was crystallized.

後処理

  1. temperatureAfter cooling
  2. extractionwater and extracted three times with 1N aqueous hydrochloric acid
  3. extractionThe combined aqueous phases were extracted three times with ethyl acetate
  4. customThe combined organic phases were dried on sodium sulfate
  5. concentrationconcentrated by evaporation in a vacuum
  6. customthe residue was crystallized

出典と根拠

ORDレコード
ord-aefc4f6bdadd41ef8f4eb405ebd21e51
出典データセット
uspto-grants-2008_02
特許番号
US07329679B2

関連ノート

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