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Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone | HCID 9885359 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride | HCID 131726767 | — |
反応手順
For salt formation, 1N hydrochloric acid is added to a solution of {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone in 60 ml of acetone and 50 ml of ether until crystals form. When crystallisation is complete, the mother liquor is filtered off, and the precipitate is washed with ether and dried, giving {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride, m.p. 238-240°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329749B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-d0a23f68871b41f4a282286bf96a4ab9 |
| 出典メモ | uspto-grants-2008_02 |