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Thionyl Chloride → {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| 反応物 | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| 反応物 | Isoquinoline-3-carbonyl chloride | HCID 22064853 | — |
| 生成物 | {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone | HCID 44215581 | — |
反応手順
Analogously to Example 3, firstly isoquinoline-3-carboxylic acid is reacted with thionyl chloride, and the resultant isoquinoline-3-carbonyl chloride is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine, giving {4-[2-(4-fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329749B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-12574c840ca043dda608e9a7b995a546 |
| 出典メモ | uspto-grants-2008_02 |