Cyanuric chloride → HCID 59656634、化合物

HRID 2054909ノート

反応式

HRID 2054909 の反応式
[NH2:1][C:2]1[C:3]2[C:13]([O:14][CH:15]3[CH2:18][CH2:17][CH2:16]3)=[CH:12][CH:11]=[C:10]([C:19]([NH2:21])=O)[C:4]=2[S:5][C:6]=1[C:7]([NH2:9])=[O:8].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C=O)C.O>[NH2:1][C:2]1[C:3]2[C:13]([O:14][CH:15]3[CH2:18][CH2:17][CH2:16]3)=[CH:12][CH:11]=[C:10]([C:19]#[N:21])[C:4]=2[S:5][C:6]=1[C:7]([NH2:9])=[O:8]

参加物

5

反応物 2

HCID 7954Cyanuric chlorideHCID 11301190Benzo[b]thiophene-2,7-dicarboxamide, 3-amino-4-(cyclobutyloxy)-

生成物 1

HCID 59656634HCID 59656634、化合物収率 48.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of the above amide (200 mg, 0.655 mmol) in DMF (3 mL) was added cyanuric chloride (60 mg, 0.325 mmol). The reaction was stirred at room temperature for 1 h. The mixture was slowly diluted with water (10 mL) and extracted with dichloromethane. The aqueous phase was allowed to stand for two weeks then the precipitate formed was collected by filtration, rinsed with MeOH and dried in vacuo to give the title compound (93.5 mg, 0.315 mmol, 48.1%).

後処理

  1. extractionextracted with dichloromethane
  2. waitto stand for two weeks
  3. customthe precipitate formed
  4. filtrationwas collected by filtration
  5. washrinsed with MeOH
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-f01a7c06250f46ffaf6f80cb87feb27d
出典データセット
uspto-grants-2008_02
特許番号
US07329764B2

反応ノート

読み込み中…