Methylamine → HCID 21948911、化合物
反応式
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4].[CH3:16][NH2:17]>>[CH3:16][NH:17][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4]参加物
3
実験手順
76 mg (0.376 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved with 10 ml of a 2.0 M methanolic methylamine solution. After 90 minutes under reflux and another 16 hours at room temperature, the solvent is removed under reduced pressure, and the residue is purified on silica gel with hexane-ethyl acetate (0-80%). 72 mg (95% of theory) of the product is obtained.
後処理
- customthe solvent is removed under reduced pressure
- customthe residue is purified on silica gel with hexane-ethyl acetate (0-80%)
- custom72 mg (95% of theory) of the product is obtained
出典と根拠
- ORDレコード
- ord-190b2443319d4cdd99f5ad69883aa279
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07329753B2
反応ノート
読み込み中…