化工社化工社 化学情報印刷レポート · 研究参考用
Benzoyl Peroxide → 2-Bromomethyl-5-nitroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-Methyl-5-nitroquinoline | HCID 294867 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2-Bromomethyl-5-nitroquinoline | HCID 21948849 | — |
反応手順
A solution that consists of 800 mg (4.25 mmol) of 5-nitro-2-methylquinoline in 20 ml of tetrachloromethane is mixed with 11 mg (0.04 mmol) of benzoyl peroxide and 794 mg (4.46 mmol) of N-bromosuccinimide. The reaction mixture is allowed to reflux for 8 hours in the presence of UV light. Insoluble components are filtered off, and the filtrate is concentrated by evaporation. After purification on silica gel with hexane-ethyl acetate (0-100%), 320 mg (28% of theory) of the product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329753B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-3e389f0f6808488994d73c8633e82fb4 |
| 出典メモ | uspto-grants-2008_02 |