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Morpholine → 2-(Morpholin-4-ylmethyl)-5-nitroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Bromomethyl-5-nitroquinoline | HCID 21948849 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(Morpholin-4-ylmethyl)-5-nitroquinoline | HCID 21948800 | — |
反応手順
460 mg (1.72 mmol) of 2-bromomethyl-5-nitroquinoline and 0.54 ml (6.2 mmol) of morpholine are dissolved in 150 ml of toluene. After 1.07 g (7.74 mmol) of potassium carbonate is added, the reaction mixture is allowed to reflux for 2 hours. Potassium carbonate is filtered off, and the filtrate is concentrated by evaporation. After purification on silica gel with hexane-ethyl acetate (0-100%), 190 mg (40% of theory) of the product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07329753B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-791d296a7b4d4d38abdcdeb174c73b6b |
| 出典メモ | uspto-grants-2008_02 |