Formamide → HCID 135553012、化合物
反応式
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][C:8]([Cl:12])=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:13]([NH2:15])=O>>[Br:11][C:10]1[CH:9]=[C:8]([Cl:12])[CH:7]=[C:3]2[C:2]=1[N:1]=[CH:13][NH:15][C:4]2=[O:5]参加物
3
実験手順
8-Bromo-6-chloro-4(3H) quinazolinone was prepared from 2-amino-3-bromo-5-chlorobenzoic acid (10 g, 40 mmol). The acid was heated in excess formamide (50 mL) at reflux overnight. The mixture was cooled and quenched with water. The solid that formed was washed with acetonitrile, 6.7 g crude (65%); MS: 260.8 (M+H)+
後処理
- temperatureat reflux overnight
- temperatureThe mixture was cooled
- customquenched with water
- customThe solid that formed
- washwas washed with acetonitrile, 6.7 g crude (65%)
出典と根拠
- ORDレコード
- ord-4dd82de2a8234fc5b58672625743b906
- 出典データセット
- uspto-grants-2008_02
- 特許番号
- US07332506B2
反応ノート
読み込み中…