Hydroxylamine → HCID 178495721、化合物

HRID 20557

反応式

HRID 20557 の反応式
[NH2:1][OH:2].[C:3]([C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1)#[N:4]>C(O)C>[OH:2][NH:1][C:3](=[NH:4])[C:5]1[CH:32]=[CH:31][C:8]([O:9][C:10]2[CH:11]=[C:12]([CH:22]=[C:23]([O:25][C@@H:26]([CH3:30])[CH2:27][O:28][CH3:29])[CH:24]=2)[C:13]([NH:15][C:16]2[CH:20]=[CH:19][N:18]([CH3:21])[N:17]=2)=[O:14])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 787HydroxylamineHCID 116543663-(4-cyanophenoxy)-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

生成物 1

HCID 178495721HCID 178495721、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Hydroxylamine (50% w/w solution, 1 mL) was added to absolution of 3-(4-cyanophenoxy)-5-[(1S)-2-methoxy-(1-methylethyl)oxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide (300 mg, 0.74 mmol) in ethanol (3 mL) and the reaction mixture allowed to stir at RT for 18 hours. The volatiles were removed in vacuo to give the desired compound as a colourless foam (325 mg).

後処理

  1. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-7a6808c0ea414610b8722719b8b97a43
出典データセット
uspto-grants-2010_06
特許番号
US07745475B2

関連ノート

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