Triethylamine → N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

HRID 2055909ノート

反応式

HRID 2055909 の反応式
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9](CCCCCCCCCCCCCCC)[C:5]=1[C:6](Cl)=[O:7])[CH3:2].[NH2:28][C:29]1[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[C:31]([C:37]([F:40])([F:39])[F:38])[CH:30]=1.C(N(CC)CC)C>ClCCl>[C:33]([C:32]1[CH:35]=[CH:36][C:29]([NH:28][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2[O:3][CH2:1][CH3:2])=[CH:30][C:31]=1[C:37]([F:38])([F:39])[F:40])#[N:34]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 102500672-ethoxy-6-pentadecyl-benzoyl Chloride

生成物 1

HCID 68453779N-(4-cyano-3-(trifluromethyl)phenyl)-2-ethoxybenzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-ethoxy-6-pentadecyl-benzoyl chloride was condensed with 4-Amino-2-trifluromethyl benzonitrile in dichloromethane in presence of triethylamine as acid scavenger to yield N-(4-Cyano-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

出典と根拠

ORDレコード
ord-7153f2bbb8684b26a6a14637d7716a44
出典データセット
uspto-grants-2008_02
特許番号
US07332629B2

反応ノート

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