1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 11699419、化合物

HRID 2056556ノート

反応式

HRID 2056556 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]=[N:14][C:15](Cl)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1.[N:21]1([C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:35]([F:38])([F:37])[F:36])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]2[N:13]=[N:14][C:15]([N:24]3[CH2:25][CH2:26][N:21]([C:27](=[O:28])[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[C:35]([F:38])([F:36])[F:37])[CH2:22][CH2:23]3)=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 86025943HCID 86025943、化合物

生成物 1

HCID 11699419HCID 11699419、化合物

実験手順

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid [2-(4-chlorophenoxy)ethyl]amide in place of 6-chloro-pyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (13% yield). 1H NMR (400 MHz, CDCl3) δ 8.27, 8.05, 7.74, 7.64, 7.57, 7.37, 7.25-7.20, 7.00, 6.85-6.82, 4.02-3.32.

出典と根拠

ORDレコード
ord-c7efcacef6a948028f5761fe9564bb5e
出典データセット
uspto-grants-2008_02
特許番号
US07335658B2

反応ノート

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