5-Isocyanatoisoquinoline → HCID 10386145、化合物

HRID 2056885ノート

反応式

HRID 2056885 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:16])[C:9]=1[N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[CH2:5][NH2:6].[N:17]([C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH:22]=[CH:23][N:24]=[CH:25]2)=[C:18]=[O:19]>C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([F:16])[C:9]=1[N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[CH2:5][NH:6][C:18]([NH:17][C:20]1[CH:29]=[CH:28][CH:27]=[C:26]2[C:21]=1[CH:22]=[CH:23][N:24]=[CH:25]2)=[O:19]

参加物

4

反応物 2

HCID 115863575-IsocyanatoisoquinolineHCID 22337573[3,5-Difluoro-4-(morpholin-4-yl)phenyl]methanamine

生成物 1

HCID 10386145HCID 10386145、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The product from Example 177A (500 mg, 2.19 mmol) in diethyl ether (5 mL) was treated with an ethereal solution of 5-isocyanatoisoquinoline. The resulting waxy precipitate was collected by filtration and air-dried to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ 9.27 (s, 1H), 8.79 (s, 1H), 8.54 (d, 1H, J=6.1 Hz), 8.26 (dd, 1H, J=7.8 Hz, 1.0 Hz), 7.94 (d, 1H, 6.1 Hz), 7.76 (d, 1H, 8.2 Hz), 7.60 (t, 3H, J=7.6 Hz), 7.10 (t, 1H, J=6.0 Hz), 7.03 (m, 2H), 4.31 (d, 2H), 3.68 (m, 4H), 3.07 (m, 4H); MS (ESI+) m/z 399 (M+H).

後処理

  1. filtrationThe resulting waxy precipitate was collected by filtration
  2. customair-dried

出典と根拠

ORDレコード
ord-c9286969418b4fc9ab601f4da284240b
出典データセット
uspto-grants-2008_02
特許番号
US07335678B2

反応ノート

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