化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1,4-Benzenedicarboxylic acid, 2,5-bis[(4-methoxyphenyl)amino]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 3-Nitrobenzenesulfonic acid | HCID 7387 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Dimethyl 2,5-bis{(4-methoxyphenyl)amino}cyclohexa-1,4-diene-1,4-dicarboxylate | HCID 14745936 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1,4-Benzenedicarboxylic acid, 2,5-bis[(4-methoxyphenyl)amino]- | HCID 3084837 | 98% |
反応手順
Dimethyl 2,5-bis{(4-methoxyphenyl)amino}cyclohexa-1,4-diene-1,4-dicarboxylate (6.58 gm, 15 mmol), the sodium salt of 3-nitrobenzenesulphonic acid (3.6 gm; 16 mmol), ethanol (90 ml) and 1.0M sodium hydroxide (50 ml) were heated to reflux overnight under a nitrogen atmosphere. The orange solution was allowed to cool and water (120 ml) was added. The mixture was acidified with conc. hydrochloric acid when a purple solid precipitated out. This material was filtered off, washed with water, then 25% ethanol/water and dried under vacuum over phosphorous pentoxide to give 6.0 gm (98%) of 2,5-bis{(4-methoxyphenyl)amino}terephthalic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07335771B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-91f2f8b86de645e5ac4b183a00b4e1c0 |
| 出典メモ | uspto-grants-2008_02 |