Morpholine → Moclobemide

HRID 2057461

反応式

HRID 2057461 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:7])=[CH:11][CH:12]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 2450271-(4-Chlorobenzoyl)aziridine

生成物 1

HCID 4235Moclobemide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

55.4 G. of p-chlorobenzoylaziridine and 26.5 g. of morpholine are boiled in 250 ml. of toluene for 2 hours under reflux. The solution is then cooled to room temperature, whereupon crystals separate out. The solution which crystallizes is allowed to stand overnight in a refrigerator. Thereafter, the product is removed by filtration, washed with toluene and recrystallized from isopropanol, and 75.9 g. of p-chloro-N-(2-morpholinoethyl)-benzamide are obtained, which is identical to the product obtained in Example 1.

後処理

  1. customseparate out
  2. customThe solution which crystallizes
  3. customThereafter, the product is removed by filtration
  4. washwashed with toluene
  5. customrecrystallized from isopropanol, and 75.9 g

出典と根拠

ORDレコード
ord-6a997b4ee6b14561a49738f88756156d
出典データセット
uspto-grants-1980_07
特許番号
US04210754

関連ノート

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