Ammonia → Moclobemide

HRID 2057462

反応式

HRID 2057462 の反応式
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][CH2:9][CH2:10]Cl)=[O:7])=[CH:4][CH:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.N>O>[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([NH:8][CH2:9][CH2:10][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 8083MorpholineHCID 2339784-Chloro-n-(2-chloroethyl)benzamide

生成物 1

HCID 4235Moclobemide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5.45 G. of p-chloro-N-(2-chloroethyl)-benzamide and 8.7 g. of morpholine are stirred together for 2 hours at 100° C. The mixture is cooled to room temperature and 50 ml. of water are added. Then, the mixture is rendered basic with 10% ammonia solution and extracted three times with 50 ml. of methylene chloride each time. The methylene chloride extract is dried over sodium sulfate and evaporated. The residue is chromatographed over a silica gel column with a mixture of chloroform and ethanol. The product is recrystallized from isopropanol, and 2.2 g. of p-chloro-N-(2-morpholinoethyl)-benzamide are obtained, which is identical to the product obtained in Example 1.

後処理

  1. extractionextracted three times with 50 ml
  2. extractionThe methylene chloride extract
  3. dry with materialis dried over sodium sulfate
  4. customevaporated
  5. customThe residue is chromatographed over a silica gel column with a mixture of chloroform and ethanol
  6. customThe product is recrystallized from isopropanol, and 2.2 g

出典と根拠

ORDレコード
ord-cda54c1f1dfb4de780abaac0498a0fd6
出典データセット
uspto-grants-1980_07
特許番号
US04210754

関連ノート

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