4-Toluenesulfonyl chloride → HCID 23331319、化合物

HRID 2057480ノート

反応式

HRID 2057480 の反応式
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH2:20][CH:21]([NH2:23])[CH3:22])[CH:17]=[CH:18][CH:19]=1.C(N(CC)CC)C>C1C=CC=CC=1>[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([NH:23][CH:21]([CH3:22])[CH2:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=2)(=[O:9])=[O:8])=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 8471TriethylamineHCID 1522341-(3-Methoxyphenyl)propan-2-amine

生成物 1

HCID 23331319HCID 23331319、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

A solution of p-toluenesulfonyl chloride (28.8 gm., 0.15 M) in benzene (100 ml.) was added dropwise to a solution of 2-(3-methoxyphenyl)-1-methylethylamine (23 gm., 0.139 M) and triethylamine (13 gm., 0.15 M) in benzene (200 ml.) during 30 minutes. The reaction was stirred at room temperature for 4 hours. The precipitated triethylamine hydrochloride was filtered off and the benzene solution was washed with hydrochloric acid (3 N), water and saturated brine. The benzene solution was dried over magnesium sulfate. Evaporation of the solvent afforded N-toluene-p-sulfonyl-2-(3-methoxyphenyl)-1-methylethylamine as an oil. Wt=42 gm.

後処理

  1. filtrationThe precipitated triethylamine hydrochloride was filtered off
  2. washthe benzene solution was washed with hydrochloric acid (3 N), water and saturated brine
  3. dry with materialThe benzene solution was dried over magnesium sulfate
  4. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-17c2467389794127bd40d6c69143e9d1
出典データセット
uspto-grants-1980_07
特許番号
US04210749

反応ノート

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