4-Chloro-2-nitroanisole → 5-Chloro-2-methoxyaniline
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-])=O)[CH:3]=1>[Ni]>[NH2:10][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]参加物
3
実験手順
0.037 mol (7 g) of 4-chloro-2-nitroanisole is dissolved in 100 ml of absolute alcohol and 3 g of nickel prepared by the RANEY process are added. The solution is hydrogenated at atmospheric pressure and at room temperature while stirring. The catalyst is separated and then washed with two portions of 20 ml of boiling ethanol. The alcoholic solution is concentrated under reduced pressure; the 2-amino-4-chloroanisole crystallizes.
後処理
- additionare added
- customis hydrogenated at atmospheric pressure and at room temperature
- customThe catalyst is separated
- washwashed with two portions of 20 ml of boiling ethanol
- concentrationThe alcoholic solution is concentrated under reduced pressure
- customthe 2-amino-4-chloroanisole crystallizes
出典と根拠
- ORDレコード
- ord-8d2027cedc054e0d925f8ce20ae21344
- 出典データセット
- uspto-grants-1980_07
- 特許番号
- US04211776
反応ノート
読み込み中…