4-Chloro-2-nitroanisole → 5-Chloro-2-methoxyaniline

HRID 2057571

反応式

HRID 2057571 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-])=O)[CH:3]=1>[Ni]>[NH2:10][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

参加物

3

反応物 1

HCID 666314-Chloro-2-nitroanisole

生成物 1

HCID 667635-Chloro-2-methoxyaniline

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

0.037 mol (7 g) of 4-chloro-2-nitroanisole is dissolved in 100 ml of absolute alcohol and 3 g of nickel prepared by the RANEY process are added. The solution is hydrogenated at atmospheric pressure and at room temperature while stirring. The catalyst is separated and then washed with two portions of 20 ml of boiling ethanol. The alcoholic solution is concentrated under reduced pressure; the 2-amino-4-chloroanisole crystallizes.

後処理

  1. additionare added
  2. customis hydrogenated at atmospheric pressure and at room temperature
  3. customThe catalyst is separated
  4. washwashed with two portions of 20 ml of boiling ethanol
  5. concentrationThe alcoholic solution is concentrated under reduced pressure
  6. customthe 2-amino-4-chloroanisole crystallizes

出典と根拠

ORDレコード
ord-8d2027cedc054e0d925f8ce20ae21344
出典データセット
uspto-grants-1980_07
特許番号
US04211776

関連ノート

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