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Acetic Anhydride → N-(5-Chloro-2-methoxyphenyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 5-Chloro-2-methoxyaniline | HCID 66763 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 生成物 | N-(5-Chloro-2-methoxyphenyl)acetamide | HCID 346203 | — |
反応手順
0.2 mol (31.5 g) of 2-amino-4-chloroanisole, 40 ml of absolute alcohol, 20 ml of acetic anhydride and a pinch of zinc powder are placed in a 150 ml flask; the solution is brought to reflux for 30 minutes. The reaction liquid is poured onto crushed ice. The product obtained is separated; it is crystallized in a methanol/water mixture (20/80).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04211776 |
| 出典データセット | uspto-grants-1980_07 |
| ORD ID | ord-c42d966b02af44adb9dfab5d9b71aeeb |
| 出典メモ | uspto-grants-1980_07 |