Water → HCID 178433279、化合物

HRID 2057608ノート

反応式

HRID 2057608 の反応式
Cl.[CH3:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH2:8][Cl:9].[OH2:10]>>[ClH:9].[CH3:2][C:3]1[N:4]=[CH:5][NH:6][C:7]=1[CH2:8][OH:10]

参加物

3

反応物 2

HCID 962WaterHCID 178433265HCID 178433265、化合物

生成物 1

HCID 178433279HCID 178433279、化合物収率 73%

実験手順

67 parts of 4-methyl-5-chloromethyl-imidazole hydrochloride are dissolved in 200 parts of water and the mixture is stirred for 4.5 hours at 50°-60° C. The water is then substantially distilled off under reduced pressure from a waterpump and the crystal slurry is recrystallized from ethanol, the solution being cooled in ice. 43.4 parts (73%) of 4-methyl-5-hydroxymethyl-imidazole hydrochloride of melting point 238°-240° C. are obtained (the melting point given in the literature is 240°-242° C., cf. A. J. Ewins, J. Chem. Soc. 99 (1911), 2052.

後処理

  1. distillationThe water is then substantially distilled off under reduced pressure from a waterpump
  2. customthe crystal slurry is recrystallized from ethanol
  3. temperaturethe solution being cooled in ice

出典と根拠

ORDレコード
ord-60ae61cd92994c79b2177d90834b5e8c
出典データセット
uspto-grants-1980_07
特許番号
US04211875

反応ノート

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