Ethylenediamine → 2-{3-[(2-Aminoethyl)amino]-2-hydroxypropoxy}benzamide
反応式
[C:1]([C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]1[O:10][CH2:9]1)(=[O:3])[NH2:2].[CH2:15]([NH2:18])[CH2:16][NH2:17]>>[C:1]([C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[O:6][CH2:7][CH:8]([OH:10])[CH2:9][NH:17][CH2:16][CH2:15][NH2:18])(=[O:3])[NH2:2]参加物
3
実験手順
1-(o-Carbamoylphenoxy)-2,3-epoxypropane (20 g.) is added to ethylenediamine (125 ml.) and the mixture is stirred at laboratory temperature for 1 hour and then evaporated to dryness under reduced pressure. The residue is stirred with water (150 ml.), the mixture is filtered and the filtrate is evaporated to dryness under reduced pressure. The residue is crystallised from acetonitrile and there is thus obtained as residue 1-(o-carbamoylphenoxy)-3-(β-aminoethyl) aminopropan-2-ol, m.p. 91°-93° C.
後処理
- customevaporated to dryness under reduced pressure
- stirringThe residue is stirred with water (150 ml.)
- filtrationthe mixture is filtered
- customthe filtrate is evaporated to dryness under reduced pressure
- customThe residue is crystallised from acetonitrile and there