Formic Acid → HCID 54372587、化合物

HRID 2057746ノート

反応式

HRID 2057746 の反応式
[C:1]1([NH:7][N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16](OC=O)(=[O:18])C.C(O)=O.C(OC(=O)C)(=O)C>C(Cl)Cl>[CH:16]([N:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[N:8]=[CH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:18]

参加物

6

反応物 4

HCID 284Formic AcidHCID 7918Acetic AnhydrideHCID 75269Acetic-formic anhydrideHCID 2587553-Pyridinecarbaldehyde phenylhydrazone

生成物 1

HCID 54372587HCID 54372587、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

9.85 g of 3 (prepared as described in Example 3) was dissolved in 50 ml of dry methylene chloride. 15 ml of formic acetic anhydride (prepared by mixing the appropriate amounts of formic acid and acetic anhydride) was added. The mixture was allowed to stand overnight at room temperature. The solvent was evaporated under reduced pressure. The residue was dissolved in ether. The solution was washed with sodium bicarbonate solution, dried (Na2SO4) and the solvent evaporated to give 4, as a white crystalline solid, mp 129°-132° C.

後処理

  1. additionwas added
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in ether
  4. washThe solution was washed with sodium bicarbonate solution
  5. dry with materialdried (Na2SO4)
  6. customthe solvent evaporated
  7. customto give 4

出典と根拠

ORDレコード
ord-d749a427e2544d50b8c4b7888d1299c3
出典データセット
uspto-grants-1980_07
特許番号
US04212868

反応ノート

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