Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2057845ノート

反応式

HRID 2057845 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

生成物 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

試薬・触媒・溶媒 2

HCID 16218511Pd barium sulfate触媒HCID 887Methanol溶媒

実験手順

300 g (778 mmoles) of Z-Tyr(But)-OMe (Ann. Chem. 696, 226 (1966)) are dissolved in 1 liter of methanol and hydrogenated catalytically (Pd/BaSO4 catalyst) at pH 4.5, using an auto-burette (about 2 N methanolic HCl being added). After completion of hydrogenation, the catalyst is filtered off and the filtrate is concentrated. The residue is triturated with ether.

後処理

  1. filtrationAfter completion of hydrogenation, the catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customThe residue is triturated with ether

出典と根拠

ORDレコード
ord-1056f3f79e874fd4a3a7c1eba6adf64f
出典データセット
uspto-grants-1980_07
特許番号
US04212796

反応ノート

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