Potassium Carbonate → Ethyl 5-phenylbenzofuran-2-carboxylate

HRID 2057967

反応式

HRID 2057967 の反応式
[C:1]1([C:7]2[CH:14]=[C:11]([CH:12]=O)[C:10]([OH:15])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:17](C(OCC)=O)[C:18]([O:20][CH2:21][CH3:22])=[O:19].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:15][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:12][C:11]=3[CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 69637Diethyl bromomalonateHCID 122646584-Hydroxy-(1,1'-biphenyl)-3-carbaldehyde

生成物 1

HCID 20329644Ethyl 5-phenylbenzofuran-2-carboxylate

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 0.99 g of 1A, 0.96 g of diethyl bromomalonate and 1.25 g of anhydrous potassium carbonate in 20 ml of 2-butanone was refluxed for 10 hours. The solvent was evaporated under reduced pressure. The residue was cooled, poured into 100 ml of water and extracted with ether. The extract was washed with cold 5% sodium hydroxide solution and water and then concentrated under reduced pressure. The residue was recrystallized from ethanol to give ethyl 5-phenylbenzofuran-2-carboxylate (1B), as white crystals, mp: 109°-110° C.

後処理

  1. temperaturewas refluxed for 10 hours
  2. customThe solvent was evaporated under reduced pressure
  3. temperatureThe residue was cooled
  4. additionpoured into 100 ml of water
  5. extractionextracted with ether
  6. washThe extract was washed with cold 5% sodium hydroxide solution and water
  7. concentrationconcentrated under reduced pressure
  8. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-198325f99e0341759bfdc909f8e0367d
出典データセット
uspto-grants-1980_07
特許番号
US04213998

関連ノート

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