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Methylamine → 4-(Methylamino)-3-nitrophenyl phenyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Sulfolane | HCID 31347 | — |
| 反応物 | 4-Chloro-3-nitrobenzophenone | HCID 41743 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-(Methylamino)-3-nitrophenyl phenyl ketone | HCID 96689 | — |
反応手順
11 g of 4-chloro-3-nitro-benzophenone, 20 g of methylamine, 153.4 g of methanol and 27.5 g of sulpholane are warmed to 125° for 15 hours in a closed vessel. The reaction solution is evaporated to dryness, the residue is boiled thoroughly with 400 ml of 2 N hydrochloric acid for 20 minutes and the precipitate is filtered off, washed with water and dissolved in methylene chloride. After drying over sodium sulphate and evaporating, 4-methylamino-3-nitro-benzophenone with a melting point of 198°-201° is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04213993 |
| 出典データセット | uspto-grants-1980_07 |
| ORD ID | ord-ace2d1fe7e91416598de2d7587d90002 |
| 出典メモ | uspto-grants-1980_07 |