Hydrochloric Acid → 1-Hydroxy-3-(hydroxymethyl)-8-methoxyanthracene-9,10-dione

HRID 2058149ノート

反応式

HRID 2058149 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:16]=1[C:15](=[O:17])[C:14]1[C:13]([O:18]C(=O)C)=[CH:12][C:11]([CH2:22][O:23]C(=O)C)=[CH:10][C:9]=1[C:8]2=[O:27].Cl.O>CO>[OH:18][C:13]1[C:14]2[C:15](=[O:17])[C:16]3[C:7](=[CH:6][CH:5]=[CH:4][C:3]=3[O:2][CH3:1])[C:8](=[O:27])[C:9]=2[CH:10]=[C:11]([CH2:22][OH:23])[CH:12]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10406699HCID 10406699、化合物

生成物 1

HCID 233496281-Hydroxy-3-(hydroxymethyl)-8-methoxyanthracene-9,10-dione収率 70.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The 8-methoxy-3-acetoxymethyl-1-acetoxy anthraquinone (120 mg) of Example 22 was refluxed in methanol (30 ml) with concentrated hydrochloric acid (10 ml) and water (10 ml) for three hours. The solvents and acid were evaporated off in vacuum and the residue crystallized from chloroform to obtain reddish yellow crystals (65 mg) of 1-hydroxy-3-hydroxymethyl-8-methoxy anthraquinone (formula 19). m.p. 215°-216°, ir (KBr) 3520-3460, 1670, 1635, 1585 cm-1.

後処理

  1. customThe solvents and acid were evaporated off in vacuum
  2. customthe residue crystallized from chloroform

出典と根拠

ORDレコード
ord-7c77745ef05a4cd1b27c4521c52b6407
出典データセット
uspto-grants-1980_07
特許番号
US04215062

反応ノート

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