Bromine → HCID 23349975、化合物

HRID 2058196ノート

反応式

HRID 2058196 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:5]=1[O:6][CH2:7][C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10].S(=O)(O)[O-].[Na+]>C(OCC)C>[Br:1][CH:7]([O:6][C:5]1[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:4]=1[Cl:3])[C:8](=[O:14])[C:9]([O:12][CH3:13])([CH3:11])[CH3:10]

参加物

5

反応物 3

HCID 24408BromineHCID 23349979HCID 23349979、化合物HCID 23665763Sodium Bisulfite

生成物 1

HCID 23349975HCID 23349975、化合物収率 99%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Bromine (10.73 g, 0.067 mole) was slowly added to a stirred solution of 18.6 g (0.067 mole) of 1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone in 350 ml diethyl ether containing 0.2 g aluminum chloride at about 3° C. After the addition, the mixture was stirred an additional 30 minutes, then poured into aqueous sodium bisulfite. The organic layer was separated, extracted with sodium bicarbonate solution, dried using MgSO4, and the solvent evaporated. There was thus obtained 23.6 g (99% yield) of 1-bromo-1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone.

後処理

  1. additionAfter the addition
  2. customThe organic layer was separated
  3. extractionextracted with sodium bicarbonate solution
  4. customdried
  5. customthe solvent evaporated

出典と根拠

ORDレコード
ord-86c30effc1cd423487761862734802a7
出典データセット
uspto-grants-1980_07
特許番号
US04215127

反応ノート

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