Hydrochloric Acid → 1-(2-Hydroxy-4,6-dimethylphenyl)-1-butanone

反応式

C([O:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]([CH3:14])[CH:8]=1)(=O)CCC.[Cl-].[Al+3].[Cl-].[Cl-].Cl>>[C:7]([C:12]1[C:11]([CH3:13])=[CH:10][C:9]([CH3:14])=[CH:8][C:7]=1[OH:6])(=[O:6])[CH2:8][CH2:9][CH3:10]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 532286Butyric acid, 3,5-dimethylphenyl ester

HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 42010061-(2-Hydroxy-4,6-dimethylphenyl)-1-butanone

反応条件

温度: 70 °C

実験手順

180 g. of 1-butyryloxy-3,5-dimethyl-benzene are treated at room temperature with 340 g. of aluminium chloride. The mixture is stirred for 4 hours at 90°-95° C., then cooled at 70° C., poured onto ice and 3 n aqueous hydrochloric acid and extracted with ether. The ether extract is washed with water to neutral reaction, dried over sodium sulfate and evaporated. There is obtained 2-butyryl-3,5-dimethyl-phenol, which melts at 48°-52° C. after recrystallization from petroleum ether.