Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2058398ノート

反応式

HRID 2058398 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

生成物 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

試薬・触媒・溶媒 2

HCID 16218511Pd barium sulfate触媒HCID 887Methanol溶媒

実験手順

300 g (778 mmols) of Z-Tyr(But)-OMe (Ann. Chem. 696, page 226 (1966)) were dissolved in 1 l of methanol and catalytically hydrogenated (Pd/BaSO4 catalyst) at pH 4.5 on the autoburette (addition of about 2 N methanolic HCl). When the hydrogenation was complete, the catalyst was filtered off with suction and the filtrate was concentrated. The residue was triturated with ether.

後処理

  1. filtrationthe catalyst was filtered off with suction
  2. concentrationthe filtrate was concentrated
  3. customThe residue was triturated with ether

出典と根拠

ORDレコード
ord-fc7ece1ab4804c53a69a69978249eb9c
出典データセット
uspto-grants-1980_07
特許番号
US04215037

反応ノート

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