4-[15-(Trifluoromethyl)pentadecylamino]benzoic acid → HCID 22344169、化合物

HRID 2058752ノート

反応式

HRID 2058752 の反応式
FC(F)(F)CCCCCCCCCCCCCCCN[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1.C(COC)OC.C(Cl)[Cl:37]>>[ClH:37].[C:23]([Cl:37])(=[O:24])[C:22]1[CH:26]=[CH:27][CH:19]=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 128316104-[15-(Trifluoromethyl)pentadecylamino]benzoic acidHCID 86634710Dimethoxyethane methylene chloride

生成物 1

HCID 22344169HCID 22344169、化合物

実験手順

A cold solution of 25 g. of 4-[15-(trifluoromethyl)pentadecylamino]benzoic acid in 500 ml. dimethoxyethane-methylene chloride (4:1) is prepared and dry hydrochloric acid is bubbled through the solution until no more precipitate forms. The solution is treated with 25 ml. thionyl chloride and refluxed until all of the precipitate has dissolved. The solvents are evaporated to yield 4-[15-(trifluoromethyl)pentadecylamino)]benzoyl chloride hydrochloride as an orange, semi-crystalline mass.

後処理

  1. customdry hydrochloric acid is bubbled through the solution until no more precipitate forms
  2. additionThe solution is treated with 25 ml
  3. temperaturethionyl chloride and refluxed until all of the precipitate
  4. dissolutionhas dissolved
  5. customThe solvents are evaporated

出典と根拠

ORDレコード
ord-81c3ba1b43a34151b255845c0c7870b7
出典データセット
uspto-grants-1982_03
特許番号
US04318914

反応ノート

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