Tris(2-chloroethyl)amine → Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

反応式

Cl[CH2:2][CH2:3][N:4]([CH2:8][CH2:9]Cl)[CH2:5][CH2:6]Cl.[CH3:11][O:12][CH2:13][CH2:14][OH:15]>>[CH2:3]([N:4]([CH2:8][CH2:9][O:15][CH2:14][CH2:13][O:12][CH3:11])[CH2:5][CH2:6][O:15][CH2:14][CH2:13][O:12][CH3:11])[CH2:2][O:15][CH2:14][CH2:13][O:12][CH3:11]

参加物

反応物 2

HCID 5561Tris(2-chloroethyl)amine

HCID 80192-Methoxyethanol

生成物 1

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

実験手順

To the aforesaid reaction mixture (i), 51.6 g tris(2-chloroethyl)amine chlorhydrate (0.215 moles) were added. The mixture was then heated with reflux of 2-methoxyethanol (125° C.) for 12 hours, followed by the distillation of the solvent under reduced pressure. The excess sodium 2-methoxyethanolate was then neutralized by addition of 11.6 cm3 aqueous HCl (10 N). The sodium chloride was filtered off and the solution distilled.

後処理

additionwere added
temperatureThe mixture was then heated
distillationfollowed by the distillation of the solvent under reduced pressure
additionThe excess sodium 2-methoxyethanolate was then neutralized by addition of 11.6 cm3 aqueous HCl (10 N)
filtrationThe sodium chloride was filtered off
distillationthe solution distilled

出典と根拠

ORDレコード: ord-3afec1d7478842e7b19584f7dd5ff4f3
出典データセット: uspto-grants-1982_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04322369

反応ノート

読み込み中…

参加物