Plomestane → HCID 86738325、化合物

HRID 2059304ノート

反応式

HRID 2059304 の反応式
[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH2:6][CH2:5]2)[C:2]#[CH:3]>O1CCOCC1.CCOCC>[CH2:1]([C@@:4]12[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16](=[O:22])[CH2:15][CH2:14]4)[CH2:11][CH2:10][C:9]1=[CH:8][C:7](=[O:23])[CH:6]=[CH:5]2)[C:2]#[CH:3]

参加物

4

反応物 1

HCID 9904788Plomestane

生成物 1

HCID 86738325HCID 86738325、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 150 mg of 10-(2-propynyl)-estr-4-ene-3,17-dione, and 300 mg of dichlorodicyanoquinone in 10 ml of dioxane is refluxed for 20 hours. The mixture is cooled and diluted with ether and then washed with aqueous sodium carbonate and dried. The solvent is evaporated and the residue is chromatographed on silica gel in ethyl acetate/hexane to give 10-(2-propynyl)-estra-1,4-diene-3,17-dione melting at about 200°-201° C. This compound has the following structural formula ##STR11##

後処理

  1. temperatureis refluxed for 20 hours
  2. temperatureThe mixture is cooled
  3. washwashed with aqueous sodium carbonate
  4. customdried
  5. customThe solvent is evaporated
  6. customthe residue is chromatographed on silica gel in ethyl acetate/hexane

出典と根拠

ORDレコード
ord-4826164723a24b618e15a576aa0fbd0e
出典データセット
uspto-grants-1982_03
特許番号
US04322416

反応ノート

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