4-(Trifluoromethyl)benzaldehyde → 201164-14-9

HRID 2059450ノート

反応式

HRID 2059450 の反応式
O=Cc1ccc(C(F)(F)F)cc1.CON(C)C(=O)CC(=O)O>NCc1ccccc1.O=C(O)C(F)(F)F.CN(C)c1ccncc1.CN(C)C=O>CON(C)C(=O)/C=C/c1ccc(C(F)(F)F)cc1

参加物

6

反応物 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 11263568HCID 11263568、化合物

生成物 1

HCID 9449823201164-14-9収率 71%

試薬・触媒・溶媒 3

HCID 142844-(Dimethylamino)pyridine試薬HCID 12484433Benzenemethanamine, trifluoroacetate触媒HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

後処理

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic 相を保持
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

出典と根拠

ORDレコード
ord-983bcc712e8641be92d7f0dabc0d5b50
出典データセット
Transfer learning optimization of 26 decarboxylative olefination reactions

反応ノート

読み込み中…