3-Aminoazetidine, 3-BOC protected → 4'-(3-aminoazetidin-1-yl)-6',7'-dihydro-5'H-spiro[cyclopentane-1,8'-quinazolin]-2'-amine
反応式
[NH:1]1[CH2:4][CH:3]([NH:5]C(=O)OC(C)(C)C)[CH2:2]1.CC1C=CC(S(O[C:24]2[C:33]3[CH2:32][CH2:31][CH2:30][C:29]4([CH2:37][CH2:36][CH2:35][CH2:34]4)[C:28]=3[N:27]=[C:26]([NH2:38])[N:25]=2)(=O)=O)=CC=1>>[NH2:5][CH:3]1[CH2:2][N:1]([C:24]2[C:33]3[CH2:32][CH2:31][CH2:30][C:29]4([CH2:37][CH2:36][CH2:35][CH2:34]4)[C:28]=3[N:27]=[C:26]([NH2:38])[N:25]=2)[CH2:4]1参加物
3
実験手順
The title compound was prepared according to the procedures of Examples 1G and 1H, substituting tert-butyl azetidin-3-ylcarbamate for the product from Example 1D. 1H NMR (300 MHz, CDCl3) δ 4.49 (br, 2H), 3.33 (m, 4H), 2.38-2.52 (m, 3H), 2.02-2.22 (m, 4H), 1.79-1.93 (m, 2H), 1.53-1.68 (m, 6H). MS (DCI+) m/z 274 (M+H).
出典と根拠
- ORDレコード
- ord-9a3e9255b18f46efa0612fdeb38fc978
- 出典データセット