Hydrate;hydrochloride → 3-Aza-spiro[5.5]undecan-9-one hydrochloride

HRID 2059920ノート

反応式

HRID 2059920 の反応式
[O:1]=[C:2]1[CH2:19][CH2:18][C:5]2([CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH:3]1C(OC)=O.[ClH:24].O>>[ClH:24].[CH2:10]1[C:5]2([CH2:18][CH2:19][C:2](=[O:1])[CH2:3][CH2:4]2)[CH2:6][CH2:7][NH:8][CH2:9]1

参加物

3

反応物 2

HCID 21885828Hydrate;hydrochlorideHCID 67315804HCID 67315804、化合物

生成物 1

HCID 673158423-Aza-spiro[5.5]undecan-9-one hydrochloride

実験手順

To 3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate (450 mg, 1.38 mmol) was added HCl—H2O (5 ml, 1:1) at 0° C. and the mixture was refluxed overnight. LCMS revealed complete consumption of the starting material and the mixture was concentrated to dryness. The crude product thus obtained was used directly in next step.

後処理

  1. temperaturethe mixture was refluxed overnight
  2. customconsumption of the starting material
  3. concentrationthe mixture was concentrated to dryness

出典と根拠

ORDレコード
ord-67fe3e5ed43e4967bd792dcb48cac8bd
出典データセット
uspto-grants-2012_10
特許番号
US08278319B2

反応ノート

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