関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tetramethoxypropane | HCID 66019 | — |
| 反応物 | 4-(Methylsulphonyl)phenylhydrazine | HCID 70142 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-(4-methanesulfonyl-phenyl)-1H-pyrazole | HCID 21478015 | 79% |
反応手順
To a solution of 4-(methylsulfonyl)phenylhydrazine (5.0 g, 26.8 mmol, 1.00 equiv) and 1,1,3,3-tetramethoxypropane (4.4 mL, 26.8, 1.0 equiv) in ethanol (37 mL) at rt was added concentrated HCl (2.8 mL). The resulting solution was heated at reflux for 1 hr, cooled to 0° C. and filtered to give 1-(4-methanesulfonyl-phenyl)-1H-pyrazole as a yellow solid (4.73 g, 79%). LCMS: (MH)+=223.1 (1.19 min).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08278337B2 |
|---|
| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-cf5f16db644e423890a415b90ce6cc83 |
|---|
| 出典メモ | uspto-grants-2012_10 |
|---|
