Furfural → 5-Furan-2-yl-3-hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-1,5-dihydro-pyrrol-2-one

HRID 2060320ノート

反応式

HRID 2060320 の反応式
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH:15]=O.C([O:19][C:20](=O)[C:21](=[O:28])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])C>C(O)C>[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[CH:15]1[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:20](=[O:19])[C:21]([OH:28])=[C:22]1[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

参加物

5

反応物 3

HCID 7362FurfuralHCID 787361H-Imidazole-1-propanamineHCID 10888659Ethyl 2-oxooctanoate

生成物 1

HCID 579240955-Furan-2-yl-3-hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-1,5-dihydro-pyrrol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and Furan-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-octanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

後処理

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

出典と根拠

ORDレコード
ord-1744b439609d4f2e86b9c88172d0c475
出典データセット
uspto-grants-2012_10
特許番号
US08278345B2

反応ノート

読み込み中…