Potassium Carbonate → 6-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile

HRID 2060878ノート

反応式

HRID 2060878 の反応式
[OH:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[C:5]([CH:11]=[O:12])=[CH:4][CH:3]=1.Cl[C:14]1[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][N:15]=1.C([O-])([O-])=O.[K+].[K+]>S1(CCCC1)(=O)=O>[CH:11]([C:5]1[C:6]2[CH:10]=[CH:9][S:8][C:7]=2[C:2]([O:1][C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][N:15]=2)=[CH:3][CH:4]=1)=[O:12]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 594013507-Hydroxybenzo[b]thiophene-4-carbaldehyde

生成物 1

HCID 594013616-(4-Formylbenzo[b]thiophen-7-yloxy)nicotinonitrile

試薬・触媒・溶媒 1

HCID 31347Sulfolane溶媒

反応条件

温度
80 °C

実験手順

A suspension of 7-hydroxybenzo[b]thiophene-4-carbaldehyde (Preparation 69) (100 mg, 0.62 mmol), 6-chloronicotinonitrile (86 mg, 0.62 mmol) and K2CO3 (258 mg, 1.87 mmol) in sulfolane (3 mL) was heated in a microwave reactor at 130 W/80° C. for 4 h. The mixture was cooled, poured onto ice water and the resulting solid filtered and air-dried to give the title compound: RT=3.40 min; m/z (ES+)=265.2 [M+H]+.

後処理

  1. temperatureThe mixture was cooled
  2. additionpoured onto ice water
  3. filtrationthe resulting solid filtered
  4. customair-dried

出典と根拠

ORDレコード
ord-11d83db49da44793b4e419b4065382ca
出典データセット
uspto-grants-2012_10
特許番号
US08278442B2

反応ノート

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