関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (alphaS)-alpha-(Chloromethyl)-3,4-difluorobenzenemethanol | HCID 25324204 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (2S)-2-(3,4-Difluorophenyl)oxirane | HCID 30070539 | 96% |
反応手順
A mixture of (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol (net 11.47 g, 59.5 mmol), toluene (25.23 g), sodium hydroxide (2.53 g, 1.06 molar equivalents) and water (24.25 g) was stirred and heated at 40° C. for 1 hour. The organic layer was separated, washed with water, and concentrated under reduced pressure. (2S)-2-(3,4-difluorophenyl)oxirane was obtained as resultant concentrate (net 8.94 g, yield: 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08278475B2 |
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| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-8b8680fcb55a40d3bd87b75739f78f66 |
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| 出典メモ | uspto-grants-2012_10 |
|---|
