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Hydrazine hydrate (1:1) → 2371-31-5
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Glycine, N-(4-chlorophenyl)-, ethyl ester | HCID 302644 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2371-31-5 | HCID 302647 | 59% |
反応手順
Ethyl 2-(4-chlorophenylamino)acetate (A) (25.6 g, 120 mmol) and hydrazine monohydrate (7.0 mL, 144 mmol) were heated to reflux in ethanol (120 mL) for 22 hours. After concentration in vacuo, the solid obtained was recrystallised from ethanol to yield the title compound (14.0 g, 59%) as a pale brown powder. 1H NMR (400 MHz, CDCl3) δ 3.85 (2H, d), 4.18 (2H, br), 6.53 (2H, d), 7.16 (2H, d), 7.60 (1H, br).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08283351B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-4de39e719876495c897ec661c521281c |
| 出典メモ | uspto-grants-2012_10 |