Hydrochloric Acid → Hydrochloric Acid

HRID 2061468ノート

反応式

HRID 2061468 の反応式
[F:1][C:2]1[C:10]2[NH:9][C:8](=[O:11])[N:7]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:6]=2[CH:5]=[C:4]([CH3:25])[CH:3]=1.[ClH:26]>ClCCl.O1CCOCC1>[ClH:26].[F:1][C:2]1[C:10]2[NH:9][C:8](=[O:11])[N:7]([CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[C:6]=2[CH:5]=[C:4]([CH3:25])[CH:3]=1.[ClH:26]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 596832531,1-Dimethylethyl 4-(4-fluoro-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

生成物 2

HCID 313Hydrochloric AcidHCID 686240254-Fluoro-6-methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

1,1-Dimethylethyl 4-(4-fluoro-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate D4 (0.072 mmol, 25 mg) was dissolved in dichloromethane (5 ml) and was treated with HCl (3 ml of a 4M solution in 1,4-dioxane) at room temperature; the mixture was stirred at room temperature for two hours. Solvent was evaporated to afford the title compound, mono hydrochloride salt, M++H=250.

後処理

  1. customSolvent was evaporated

出典と根拠

ORDレコード
ord-cd0304d097054ecd9e3323a19e77ae7e
出典データセット
uspto-grants-2012_10
特許番号
US08283364B2

反応ノート

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