Water → 2-(trifluoromethyl)-1H-indole-5-carbonitrile
反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]2C(O)=O)#[N:2].O>CN1C(=O)CCC1>[F:15][C:12]([F:13])([F:14])[C:7]1[NH:8][C:9]2[C:5]([CH:6]=1)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=2参加物
4
反応条件
- 温度
- 135 °C
実験手順
5-cyano-2-(trifluoromethyl)-1H-indole-3-carboxylic acid (Intermediate 13, 2.09 g) was dissolved in NMP (10 mL) and H2O (1 mL) was then added. The mixture was heated to 130-140° C. overnight under nitrogen. The solution was cooled to room temperature and H2O (30 mL) was added and the solution stirred for 40 min. and then filtered. The cake was washed with H2O. The product is then dried under vacuum at 40° C. to give the title compound (1.42 g);
後処理
- temperatureThe solution was cooled to room temperature
- filtrationfiltered
- washThe cake was washed with H2O
- customThe product is then dried under vacuum at 40° C.
出典と根拠
- ORDレコード
- ord-a5d6f8507c3b4b8d9e6d0f644a062501
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08283365B2
反応ノート
読み込み中…