Sodium Chloride → 7-(3-Bromophenyl)-9-azabicyclo[3.3.1]nonan-3-one

HRID 2061612ノート

反応式

HRID 2061612 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:15][CH:14]3[NH:16][CH:10]([CH:11](C(OC)=O)[C:12](=[O:21])[CH:13]3C(OC)=O)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[Na+].[Cl-]>CS(C)=O.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:15][CH:14]3[NH:16][CH:10]([CH2:11][C:12](=[O:21])[CH2:13]3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 5234Sodium ChlorideHCID 70230991Dimethyl 7-(3-bromophenyl)-3-oxo-9-azabicyclo[3.3.1]nonane-2,4-dicarboxylate

生成物 1

HCID 673036667-(3-Bromophenyl)-9-azabicyclo[3.3.1]nonan-3-one

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Dimethyl 7-(3-bromophenyl)-3-oxo-9-azabicyclo[3.3.1]nonane-2,4-dicarboxylate (89) and NaCl (61.22 g, 1.05 mol) in DMSO (200 ml) and water (10 ml) was placed into a preheated oil bath at 160° C. After stirring for 14 h, the solution was cooled to ambient temperature and exhaustively extracted with EtOAc. The combined organic extracts were dried over MgSO4, filtered, and concentrated to afford compound 90.

後処理

  1. extractionexhaustively extracted with EtOAc
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-4b4e305ce1ec41c4b85240dccfa7e403
出典データセット
uspto-grants-2012_10
特許番号
US08283358B2

反応ノート

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