Ammonia → HCID 67029027、化合物
反応式
[C:1]([O:5][C:6]([N:8](C(OC(C)(C)C)=O)[C:9]1[CH:10]=[C:11]([C:16]([Br:19])=[CH:17][N:18]=1)[C:12](OC)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:27]>CO>[Br:19][C:16]1[C:11]([C:12](=[O:13])[NH2:27])=[CH:10][C:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[N:18][CH:17]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A solution of methyl 2-(bis(tert-butoxycarbonyl)amino)-5-bromoisonicotinate (Intermediate 83, 100 g, 232 mmol) in 7 N ammonia in methanol (600 mL) was allowed to stir at 50° C. in a 1 L sealed tube overnight. The resulting mixture was evaporated to dryness and the crude product was directly used for the next step without further purification.
後処理
- customsealed tube overnight
- customThe resulting mixture was evaporated to dryness
- customthe crude product was directly used for the next step without further purification
出典と根拠
- ORDレコード
- ord-85c01f4f694b483b817b39e11631e9df
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08283361B2
反応ノート
読み込み中…