4-Phenylpiperidine → 1-Piperidinesulfonamide, 4-phenyl-

HRID 2061915ノート

反応式

HRID 2061915 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[S:13](N)([NH2:16])(=[O:15])=[O:14]>O1CCOCC1>[NH2:16][S:13]([N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)(=[O:15])=[O:14]

参加物

4

反応物 2

HCID 698734-PhenylpiperidineHCID 82267Sulfamide

生成物 1

HCID 119990221-Piperidinesulfonamide, 4-phenyl-

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

4-Phenyl-piperidine (10 g, 62 mmol) was dissolved in dioxane (100 mL). Sulfamide (23.8 g, 248 mmol) was then added and the reaction mixture heated to 100° C. for 14 h. The reaction mixture was then cooled to room temperature, quenched by addition of 1N HCl and then concentrated to remove dioxane. The product was extracted with ethyl acetate (100 mL), dried (Na2SO4), filtered and concentrated to yield the title compound as a light brown solid.

後処理

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. customquenched by addition of 1N HCl
  3. concentrationconcentrated
  4. customto remove dioxane
  5. extractionThe product was extracted with ethyl acetate (100 mL)
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-d0a30a179f2d44099ca63f03c1ba702d
出典データセット
uspto-grants-2012_10
特許番号
US08283478B2

反応ノート

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