1-(4-Benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one → (R)-2-hydroxy-4-methyl-1-(piperazin-1-yl)pentan-1-one

関与物質

反応手順

To a solution of 1-(4-benzyl-piperazin-1-yl)-2-hydroxy-4-methyl-pentan-1-one (132 g) in methanol (1 L) was added Pd/C (20 g, 10% weight Pd on carbon). The reaction mixture was stirred at room temperature overnight under an atmosphere of hydrogen. The reaction mixture was filtered through Celite, and the solvent was removed in vacuo. (R)-2-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one was obtained as an oil (68 g, 74%).

情報源と証拠