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Ammonium Acetate → 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one | HCID 77174792 | — |
| 溶媒 | M-Xylene | HCID 7929 | — |
| 生成物 | 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174793 | — |
反応手順
A mixture of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (450 mg, 1.63 mmol, Example 1, Step 2), ammonium acetate (3.0 g, 39 mmol), and anhydrous m-xylene (8 mL) was refluxed under N2. After 3 h, the reaction was concentrated and purified by silica gel chromatography (3:2→0:1; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one: MS (ESI): 275.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745646B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-04761b64a3d74a64b013bacdf263a064 |
| 出典メモ | uspto-grants-2010_06 |