関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbon Tetrachloride | HCID 5943 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one | HCID 77174792 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174794 | — |
反応手順
A mixture of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (415 mg, 1.5 mmol, Example 1, Step 2), triphenylphosphine (787 mg, 3.0 mmol), CCl4 (0.75 mL, 7.8 mmol), and chloroform (2 mL) was heated at 80° C. in a sealed vial for 4.5 h and then allowed to cool to rt. The reaction was concentrated and purified by silica gel chromatography (1:0→4:1; hexanes:ethyl acetate) to give 4-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one: MS (ESI): 294.8.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07745646B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-8539f12c35a34f4a8199de73e3b5f501 |
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| 出典メモ | uspto-grants-2010_06 |
|---|
