Aniline → 1-phenyl-1H-1,2,4-triazol-3-amine

HRID 2063651ノート

反応式

C1([C:7]2O[N:10]=[C:9]([NH2:12])[N:8]=2)C=CC=CC=1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:14]1([N:13]2[CH:7]=[N:8][C:9]([NH2:12])=[N:10]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

反応物 2

HCID 6115Aniline

HCID 23054465-Phenyl-1,2,4-oxadiazol-3-amine

生成物 1

HCID 218217441-phenyl-1H-1,2,4-triazol-3-amine収率 87%

実験手順

This compound was prepared from 5-phenyl-[1,2,4]oxadiazol-3-ylamine (Journal of Organic Chemistry 28, 1812 (1963) and aniline, via the rearrangement described by Ruccia et al., Journal of Heterocyclic Chemistry 8, 137 (1971). The title compound was isolated as a slightly brownish solid in a yield of 87%. MS ISP (m/e): 161.2 (100) [(M+H)+].

出典と根拠

ORDレコード: ord-b489db41bb9b418ba091df64ab8fc0b1
出典データセット: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08288403B2

反応ノート

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